Phenotype and genotype characteristics of EPCs from different donors: This study aims to compare the genotype, phenotype and function of endothelial progenitor cells that were isolated from unrelated human donors. We found slight differences in the proliferation and migration capacities of cells from different donors. More significant differences were observed in cells' phenotype.
Revealing the pathogenesis of MRONJ: The aim of the study is to investigate the effect of medications on oral keratinocytes and gingival fibroblasts. Specifically to follow cells migration, proliferation and expression of genes that associate with wound healing.
Identify the molecule that modulates recruitment of endogenous MSCs and EPCs, revealing the molecular mechanism of MSC-EPCs interactions as a preliminary platform for a novel cell-free technology for bone regeneration.
Crosstalk between osteosarcoma cells and EPCs: We hypothesize that EPCs may contribute to tumor aggressiveness and metastasis by secretion of proangiogenic factors. We examine the presence of EPCs in osteosarcoma and correlate their levels with disease aggressiveness.
The influence of bisphosphonates on IFN β levels in inflammatory macrophages, as part of MRONJ disease phathogenesis: The aim of the study is to explore the effect of bisphosphonates on macrophage function, as part of shedding light on MRONJ pathogenesis.