The Zigdon Lab

Translational Research

Lab for Bone Repair


Principal Investigator: Prof. Hadar Zigdon-Giladi

The Zigdon lab (Bone Regeneration Lab) is located at the Clinical Research Institute at Rambam (CRIR).

Our general aim is to study methods to induce bone regeneration following fractures and severe trauma to bone using scaffolds, cells and growth factors. Specifically, we study the ability of endothelial progenitor cells (EPCs) to enhance bone regeneration. EPCs have been identified in adult bone marrow and in peripheral blood. EPCs have proliferation capacity, immaturity and participate in vessel formation in the pre and post-natal periods. Therefore, EPCs are perfect candidate to contribute to all regenerative procedure. Recent studies from our laboratory demonstrated the efficacy of EPCs to regenerate bone in a critical-size gap in rodents and large animal models.
Currently our research expanded to investigate the mechanism of EPCs in bone and blood vessel formation and to analyze the phenotype and genotype of these cells.
Our team is made of clinicians (MD) and researchers (PhD) with various expertise. We also collaborate with other leading laboratories, researchers and industries worldwide. Our vision is to improve treatments that involve bone regeneration in orthopedic, maxillofacial and neurosurgery. We envision taking cell therapy to the next level from the bench to the bed.

 Meet the Zigdon-Giladi Lab Team

The Zigdon Lab

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