The focus of our research is the optimization in the manufacture of microbiome transplants. Our work consists on the ex vivo growth of microbial communities found in healthy individuals, their manipulation through substrate enrichment, and the standardization of the whole process of lyophilization and capsule production through a quality assessment program.
Once obtained a high quality lyo-FMT, we test their capacity of implantation and overall viability both in vitro and in vivo.
With the final product- Lyo-FMT capsules, we perform clinical trials within Rambam Health Care Campus in the areas of infection control and gastroenterology. We also aim to expand the clinical research into new promising areas such as oncology, skin health, urobiome and microbiome of the reproductive tract.
We work in collaboration with many basic and clinical researchers in different fields of medicine, within Rambam and at the Technion Institute of Technology. We also collaborate with centers abroad specialized in multiomic analysis (integration of metagenomics, metabolomics, immunological profiles, resistome) who use algorithms predictive of disease progression and engraftment potential of the microbiome transplants.
Currently, our lab is the coordinator of a multicenter randomized controlled trial sponsored by JPIAMR, Joint Programming Initiative on Antimicrobial Resistance, with the support of the European commission.
JPIAMR is a global collaborative organization and platform, engaging 29 nations to curb antimicrobial resistance (AMR) with a One Health approach.
Link to our project: https://www.jpiamr.eu/projects/DONATE/
The official video: https://youtu.be/XFrgJ78mVpY