The Center's research team collaborates with researchers from Rambam, academia and leading industries to answer clinically unmet needs across the hospital's departments. Leveraging advanced technologies in the fields of stem cells, tissue engineering, 3D bioprinting, and organ-on-chip devices, the Center focuses on the following areas:
Rambam researchers have been among the first in the world to create human pluripotent stem cells (embryonic and induced pluripotent stem cells) and develop differentiation protocols for a variety of cell types. In collaboration with Rambam's Biobank, the Center uses the following cell sources for tissue formation:
iPSCs from patients with hereditary diseases
iPSCs with a heterogeneous genetic background
Adult stem cells
Primary cells from biopsies
3D printing drives significant innovations in many areas, such as engineering, manufacturing, and medicine. Recent advances have enabled 3D printing of biocompatible materials, cells, and supporting components for use as complex 3D functional living tissues. 3D bioprinting is being applied to address the need for tissues suitable for transplantation, such as multi-layered skin, bone, vascular grafts, heart tissue, and cartilaginous structures. Other applications include developing bioprinted tissue models for research, drug discovery, and toxicology.
rgans-on-chips are engineered physiological organ biomimetic systems. They simulate the organ's microenvironment in terms of tissue interfaces and mechanical stimulation, thus reflecting human tissue's structural and functional characteristics. Organ-on-chip models can help predict the response to various stimuli, including drug responses, environmental effects and molecular techniques such as CRISPR genetic editing and mRNA/siRNA-based treatments. A particularly intriguing aspect of organs-on-chips, which is of particular interest to researchers at MATRiC, is that they are a patient-specific tool and can be used for precision treatments.
The Center offers services in the fields mentioned above, from iPSC manufacturing to establishing an organ-on-chip platform. Its researchers support all the research stages, from designing experiments to operating instruments and data analysis and interpretation.
At MATRiC, we translate academic research into medical applications. We value all input and encourage inquiries for collaborations.
Please contact us for more information.
Meet the MATRiC Team
About Dr. Arbel Artzy-Schnirman