Identification of Cardiac Progenitor Cells Derived from Human Embryos – Significance for Repairing the Heart.
The Gepstein lab is dedicated to exploring new frontiers in cardiovascular regenerative medicine. Our work centers on the potential of human pluripotent stem cells, including human embryonic stem cells (hESC), for repairing damaged heart tissue caused by post-myocardial infarction heart failure. Additionally, we investigate the use of genetically-engineered cell grafts to modify myocardial electrophysiological properties, with a focus on treating cardiac arrhythmias. Our research programs specifically involving hESC aim to better understand the mechanisms of early human cardiac-lineage commitment and differentiation, including exploring the possibility of a differentiation hierarchy during this process.
The Gepstein Lab Team iPS-ChOp-AF