Microbiome Hub

Microbiome Hub

The Microbiome Hub is a net of researchers and clinicians, that study the microbial communities that live within the gut, respiratory tract, skin, and other areas of the human body. These trillions of microorganisms have an intricate relationship with the human host and its different systems, constituting a backbone indispensable for the normal functioning of metabolic processes and immune

The Microbiome Hub is a net of researchers and clinicians, that study the microbial communities that live within the gut, respiratory tract, skin, and other areas of the human body. These trillions of microorganisms have an intricate relationship with the human host and its different systems, constituting a backbone indispensable for the normal functioning of metabolic processes and immune development.
With the increasing recognition of the importance of the microbiome in human health, the Microbiome Hub plays a critical role in advancing our understanding of this complex and rapidly-evolving medical field. The ultimate purpuse is the translation of knowledge into practical applications that can improve the lives of patients suffering from a wide range of conditions.
Examples are the characterization of microbiomes in selected diseases or conditions, the manipulation of the microbial composition by additives with potential therapeutic capacity, and the transference of whole healthy microbiomes to restore the balance of disrupted microbiomes (dysbiosis).

Microbiome Hub

Rambam’s Microbiome Center brings together a team of top scientists whose field of expertise is the human microbiome and its role in the promotion of health. The Center is at the forefront of this growing field, having leveraged its professional expertise together with Rambam’s world-class healthcare ecosystem, which includes advanced research labs, topnotch medical departments and a teaching faculty.


Who we are

The Microbiome Center promotes multidisciplinary collaborations with clinicians and researchers from within Rambam and around the world who want to dive into the microbiome world. The center is headed by Dr. Milena Pitashny, MD, an experienced Clinical Microbiologist who completed her postdoctoral trainings in both Immunology (Albert Einstein College of Medicine) and Microbiome Research and Therapeutic Microbiology (Baylor College of Medicine). Her most important contributions are the combination of a clinical background with best laboratory standards in biobanking, molecular diagnostics and preparation of microbiome transplants.
Dr. Haggai Bar-Yoseph, MD, a Gastroenterologist with a postdoc in Microbiology and Microbiome Research (University of British Columbia), brings together his experience in the clinical grounds, basic and clinical research, with a strong orientation in the therapeutic potential of microbiome transplants and nutrition.
The Center has a scientific Consortium which comprises a multidisciplinary team of experts, each of whom contribute unique experience and expertise. The Microbiome Consortium includes Dr. Pitashny and Dr. Bar-Yoseph, as well as Dr. Rotem Lapidot, MD (Pediatrics and Infectious Diseases) and Dr. Amir Minerbi, MD PhD (Pain Relief). All members of the Consortium have vast experience in the microbiome field, pursued abroad in postdoctoral fellowships, including clinical, preclinical and data analysis experience.

What we do

Overall, the Microbiome Center is focused on researching the role of the microbiome in health and disease, and developing therapeutic microbiome strategies that can be used for healing unbalanced microbiomes (dysbiosis) in diverse fields of medicine. As part of routine clinical practice, the Microbiome Center treats Clostridioides difficile infections (CDI) through fecal microbiome transplants (FMT). In this process, the gut microbiome of healthy individuals is used therapeutically to restore the unbalanced microbiome of patients suffering from CDI, either in hospitalized or outpatient setups. Stool donors are thoroughly screened for potential transmissible diseases, and FMT therapy is administered in the form of capsules that contain powdered healthy microbes. In addition, this special powdered FMT product has the potential of being used in clinical trials in other fields, for example the ongoing studies on reducing gut colonization with resistant bacteria and alleviation of fibromyalgia symptoms.

The field of microbiome therapy is growing very quickly and attracting increasing global attention. Rambam’s Microbiome Center is poised to play a leading role in promoting and supporting innovative research in this promising field.

Our services

Rambam’s professional teams and cutting-edge facilities offer a comprehensive all-inclusive solution to researchers and commercial entities who are developing therapies and products in this field. The Center offers guidance throughout the research process, and support on a variety of steps, from study design, specimen collection and storage, to sequencing and bioinformatic analysis.
Proposed services include feasibility studies, preclinical studies (including animal studies), clinical trials, gathering clinical data, sequencing and metabolomics in a (wet lab), data analysis, bioinformatics and biostatistics (e-lab), and, finally, Consortium discussion and interpreting the data. These services are available either individually in a modular manner, or as an all-in-one place package.

 

 Meet the Microbiome Center Team  

 Current Clinical Trials 

Clinical and Research Microbiome Center at Rambam

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call us Call us: 04-777-1108
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