Clinical and Research Microbiome Center

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Clinical and Research Microbiome Lab

Clinical and Research Microbiome Center at Rambam

Rambam’s Microbiome Center brings together a team of top scientists whose field of expertise is the human microbiome and its role in the promotion of health. The Center is at the forefront of this growing field, having leveraged its professional expertise together with Rambam’s world-class healthcare ecosystem, which includes advanced research labs, topnotch medical departments and a teaching faculty.

The Microbiome Center promotes multidisciplinary collaborations with clinicians and researchers from around the world who want to dive into the microbiome world. The Center’s scientific consortium comprises a multidisciplinary team of experts, each of whom contributes unique experience and expertise. The team is headed by Dr. Milena Pitashny, MD, an experienced clinical microbiologist who completed post-doc research in both immunology and the microbiome, and also includes Dr. Rotem Lapidot – Pediatrics and Infectious Diseases, Dr. Amir Minerbi – Pain Relief, and Dr. Haggai Bar-Yoseph – Gastroenterology. All members of the consortium have vast experience in the microbiome field, pursued abroad in postdoctoral fellowships, including clinical, preclinical and data analysis experience.

Rambam’s professional team and cutting-edge facilities offer a comprehensive all-in-one solution to researchers and commercial entities who are developing therapies and products in this field. The Center offers guidance throughout the research process, and support on a variety of steps, from study design, specimen collection and storage to sequencing and analysis.

Proposed services include feasibility studies, preclinical studies (including animal studies), clinical trials, gathering clinical data, sequencing and metabolomics in a wet lab, data analysis using bioinformatics and biostatistics, and, finally, interpreting the data. These services are available either individually, in a modular manner, or as an all-inclusive package.
Overall, the Microbiome Center is focused on researching and developing therapeutic microbiome strategies that can be used for healing unbalanced microbiomes (dysbiosis) in diverse fields of medicine. As part of routine clinical practice, the Microbiome Center treats Clostridioides difficile infections (CDI) through fecal microbiome transplants (FMT). In this process, the gut microbiome of healthy individuals is used therapeutically to restore the unbalanced microbiome of patients suffering from CDI, either in hospitalized or outpatient setups. Stool donors are thoroughly screened for potential transmissible diseases, and FMT therapy is administered in the form of capsules that contain powdered healthy microbes. In addition, this special powdered FMT product has the potential of being used in clinical trials in other fields, for example the ongoing study on reducing gut colonization with resistant bacteria.

The field of microbiome therapy is growing very quickly and attracting increasing global attention. Rambam’s Microbiome Center is poised to play a leading role in promoting and supporting innovative research in this promising field.