The Zuckerman and Reshef Lab

תמונה ראשית- Reshef Lab

Zuckerman and Reshef Lab

Discovering the Initation Event Leading to Leukemic Cells Production

Principal Investigators: Professor Tsila Zuckerman and Dr. Shlomit Yehudai-Reshef

Our mission is to discover the initiation event leading to leukemic cells production and to use these understanding to guide the development of new therapy strategies for leukemia.

Our major goals are: to unravel leukemia heterogeneity by applying single cell approach and investigate what governs leukemia production from hematopoietic stem cell located in the bone marrow; to discover how the cross talk between mesenchymal cells and hematopoietic stem cells in the bone marrow niche are disrupted in leukemia.

We combine interdisciplinary methods such as genome sequencing, molecular, immunology, computational, functional and high resolution imaging techniques to define the interactions between bone marrow subpopulations and single leukemic stem cells.

Our studies have direct clinical implications as we are aiming to integrate advancements in disease biology with clinical trials, taking research from the “bench-to-bedside.”

Meet the Zuckerman and Reshef Lab Team>

Zuckerman and Reshef  Lab

Professor Tsila Zuckerman Professor Tsila Zuckerman

Dr. Tsila Zuckerman is Director of the Department of Hematology and Bone Marrow Transplantation at Rambam Health Care Campus and Clinical Associate Professor at the Ruth & Bruce Rappaport Faculty of Medicine of the Technion-Israel Institute of Technology.

Her teaching activities include coordination of the Preclinical-Clinical Integrated Systems course (Hemato-Oncology) for medical students, instruction of the Capsule course and consultation of clinical-year students. Dr. Zuckerman also heads the Leukemia Research Laboratory at the Clinical Research Institute at Rambam (CRIR) and mentors PhD and MSc students.

Dr. Zuckerman received her MD (with distinction) from the Faculty of Medicine at the Technion in Haifa, Israel and performed her residency in internal medicine at the Carmel Medical Center in Haifa. She went on to complete a three-year clinical and research fellowship in hemato-oncology and bone marrow transplantation (BMT) at the University of Southern California (Los Angeles, CA, USA). Upon her return to Israel, Dr. Zuckerman joined the Department of Hematology at Rambam Health Care Campus. Since 2006, she has been heading the Rambam Bone Marrow Transplantation Unit, where over 2,500 transplants have been performed to date, and the most advanced treatment approaches are being used for the benefit of both patients and BMT donors.

Dr. Shlomit Yehudai-Reshef Dr. Shlomit Yehudai-Reshef

Dr. Shlomit Yehudai-Reshef was born in Kibbutz Ma'ale Hachamisha. She completed her PhD in Biology in 2003 at the Technion – Israel Institute of Technology and pursued her postdoctoral research from 2003-2006 at Cornell University, New York, USA.

In 2008, she joined the Physics Department at the Technion, as a research-associate, where she conducted bio-physical research. This experience exposed Dr. Yehudai-Reshef to a new field in which she gained an expertise in live-cell imaging and image analysis.

In October 2012, she joined the Hematology Research Center at Rambam Health Care Campus and established the Leukemia Research Laboratory, located in the Clinical Research Institute at Rambam (CRIR), Haifa, Israel. She has been a member of the CRIR since 2016. In 2018 she was appointed CRIR vice-director.

Dr. Yehudai-Reshef is an avid believer in the synergism of collaboration between physicians and scientists and she is passionate about translational research.

Dr. Shlomit Yehudai-Reshef is currently leading the leukemia research laboratory together with Professor Tsila Zuckerman.

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