The Horowitz and Katz Lab

תמונה ראשית - הורוביץ

The Horowitz and Katz lab

Cancer Microenvironment in Hematologic Diseases

Principal Investigators: Dr. Netanel Horowitz and Dr. Tammy Katz

Hematological malignancies are developed in different tumor microenvironments (TME), such as bone marrow and lymph nodes. Hence, the TME plays a vital role in growth, survival, invasion and therapy resistance of malignant cells. Crosstalk between malignant cells and their surrounding depends on the specific organ location and patient's physiological state (e.g., pregnancy, morbidities). TME contains various accessory cells, such as stromal cells, endothelial and immune cells that trigger signaling pathways through cell-cell contact and molecular crosstalk, mediated by different secreted factors that influence tumor progression.

Our research group focuses on the investigation of interactions between TME components and lymphoproliferative malignancies developing in different TME niches. In order to better define these mechanisms, we have designed a series of in vivo and in vitro studies targeting these interfaces in several hematological cancers and disease scenarios. The study will give insight into cancer evolvement in different organs and scenarios and may improve tailored treatment of B-lymphocyte malignancies using novel therapeutic agents targeting different components of TME.

Meet the Horowitz and Katz Lab Team>

The Horowitz and Katz lab

Dr. Netanel Horowitz Dr. Netanel Horowitz

Dr. Netanel Horowitz is a senior physician and the Head of clinical trials at the Hematology Institute of Rambam Health Care Campus. He is Israeli board certified in internal medicine and hematology, and specializes in hematological malignancies and diagnosis and treatment of coagulation and bleeding disorders.

Dr. Horowitz graduated from the Technion’s Ruth & Bruce Rappaport Faculty of Medicine in 1999. After completing his residency in internal medicine and a fellowship in Hematology (2001–2008), he pursued a research fellowship in the Divisions of Hematology and Oncology at Cincinnati Children’s Hospital Medical Center (2008–2010). In 2010, Dr. Horowitz was appointed as a senior physician at the Hematology Institute of Rambam Health Care Campus. He became an associate member of the Clinical Research Institute at Rambam (CRIR) in 2013, and established his own research laboratory. The same year, Dr. Horowitz was appointed as a clinical lecturer at the Technion’s Faculty of Medicine.

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Dr. Tammy Katz Dr. Tammy Katz

Dr. Tammy Katz is head of the Stem Cell Transplantation Laboratory at Rambam Health Care Campus and a principal investigator in the Horowitz and Katz Lab in the Clinical Research Institute at Rambam (CRIR).

 

 

 

 

 

 

 

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