CRIR Members

Dr. Oren Caspi

Phone number of Dr. Oren Caspi04-7773380

Dr. Oren Caspi is the Director of the Heart Failure Unit and Head of Rambam’s Cardiovascular Research and Innovation Center. He serves as an assistant professor heading the Laboratory for Cardiovascular Precision Medicine at the Rappaport Faculty of Medicine, Technion-Israel Institute of Technology and the Clinical Research Institute at Rambam (CRIR).

Dr. Caspi earned his M.D. with honors from the Technion-Israel Institute of Technology in 2003. He conducted his Ph.D. studies in Prof. Lior Gepstein’s laboratory, focusing on strategies for myocardial regeneration using human stem cells. In his studies, he was among the pioneers to demonstrate the ability of human stem cell-derived cardiomyocytes to improve myocardial function in the infarcted myocardium, and established a technology for forming 3D human vascularized cardiac tissues. For these studies, he was awarded the Zigler Prize for Regenerative Medicine as well as the Neufeld, Rapport and the Grenadier Awards.

Dr. Caspi completed his residency in internal medicine at Rambam Health Care Campus, where he conducted his general cardiology fellowship. He was awarded the Daniel Shiran Award for the best cardiology fellow by the Israel Heart Association. Dr. Caspi is a graduate of the prestigious program for heart failure expert training at the University of Zurich (UZH) and the European Society of Cardiology.
Dr. Caspi has been trained in advanced heart failure and mechanical circulatory support at UC San Diego Health, one of the best centers in advanced heart failure in the US. In addition, he completed focused short-term trainings in both Europe and the United States in the field of mechanical circulatory support.
Dr. Caspi is the founder of the Left Ventricular assist Device (LVAD) program at Rambam and the digital health program for cardiac rehabilitation.

Dr. Caspi’s current basic research focuses on modeling genetic and acquired cardiomyopathies using the induced pluripotency technology, and on stem cell-based myocardial regeneration. Dr. Caspi’s clinical research focuses on optimizing the clinical management of acute heart failure patients using machine learning and causal inference methodologies.

Dr. Caspi is a member of the European Society of Cardiology, the Heart Failure Association and the Israel Heart Association, and he is a member in the ESC working group for myocardial regeneration.

  • Research area:Stem Cells, Heart Failure
  • Key Word:Heart failure, Organoids, Chemotherapy-induced, Cardiomyopathy
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