CRIR - Clinical Research Institute at Rambam

CRIR

The Clinical Research Institute at Rambam (CRIR). An Open, Collaborative Platform for Hospital‑Based Biomedical Discovery
The Clinical Research Institute at Rambam (CRIR) is a hospital‑embedded research platform designed to enable biomedical discovery at scale. Inspired by leading global models of open and collaborative science, CRIR operates on the principle that transformative medical research emerges when clinical insight, scientific leadership, and shared infrastructure are brought together within a single enabling ecosystem.
At the heart of CRIR is its community of investigators. The Institute is built around its members, principal investigators (PIs) who lead independent research laboratories and centers of excellence.

An Open, Collaborative Platform for Hospital‑Based Biomedical Discovery

The Clinical Research Institute at Rambam (CRIR) is a hospital‑embedded research platform designed to enable biomedical discovery at scale. Inspired by leading global models of open and collaborative science, CRIR operates on the principle that transformative medical research emerges when clinical insight, scientific leadership, and shared infrastructure are brought together within a single enabling ecosystem.
At the heart of CRIR is its community of investigators. The Institute is built around its members, principal investigators (PIs) who lead independent research laboratories and centers of excellence. These physician‑scientists and researchers define the scientific vision, drive innovation, and anchor CRIR’s research excellence. CRIR exists to empower this community by providing the infrastructure, professional support, and collaborative environment required for ambitious, high‑impact research.

A Platform That Enables Science

CRIR is not a traditional research unit but an enabling platform. It provides centralized resources, professional research support, and shared capabilities that allow investigators and clinical teams to focus on scientific and clinical questions rather than administrative or structural barriers. This model lowers the threshold for participation in research while supporting depth, rigor, and scale for established PIs and emerging investigators alike.
CRIR supports the full research lifecycle, from early‑stage idea development and study design to regulatory processes, execution, and dissemination, transforming individual research efforts into a coordinated institutional capability.

Open, Collaborative, and Cross‑Disciplinary

Aligned with Rambam’s vision as an integrated medical campus, CRIR promotes open collaboration across disciplines, departments, and professional roles. By connecting PIs, clinicians, and research teams within a shared framework, the Institute fosters cross‑fertilization of ideas and accelerates translational discovery.

Translational Impact at Scale
CRIR places strong emphasis on translational research that bridges bedside observations with scientific discovery and real‑world implementation. By centering on its PI community and embedding research within the hospital environment, CRIR accelerates the generation of knowledge, technologies, and insights that improve patient care and advance biomedical innovation.

Vision

CRIR’s long‑term vision is to position Rambam as a model for hospital‑based, platform‑driven research, where a strong community of independent investigators is supported by shared infrastructure and collective purpose, enabling biomedical discovery and impact at scale.

CRIR directors:
Prof. Michael Aviram Prof. Yehuda Chowers Dr. Shlomit Yehudai-Reshef
2008-2016 20016-2018 2018-Present

Dr. Shlomit Yehudai-Reshef, PhD, is currently the Director of the Clinical Research Institute at Rambam (CRIR). She completed her PhD in biology at the Technion – Israel Institute of Technology (Haifa, Israel), and subsequently conducted postdoctoral research at Cornell University in New York, USA.
In 2012, Dr. Yehudai-Reshef became a part of the Hematology Research Center at the Rambam Health Care Campus in Haifa, Israel. There, she established the Leukemia Research Laboratory, which is affiliated with the CRIR.

Since 2016, Dr. Yehudai-Reshef has been a member of the CRIR, and in 2018, she assumed the role of CRIR Director. She is deeply committed to fostering collaboration between physicians and scientists, and she actively promotes translational research. Driven by her vision, she aims to establish a national translational research ecosystem led by healthcare researchers. Furthermore, she actively encourages global collaborations and strives for scientific excellence within the CRIR.

Alongside her research and leadership responsibilities, Dr. Yehudai-Reshef holds the position of Senior Lecturer at the Ruth and Bruce Rappaport Faculty of Medicine at the Technion in Haifa, Israel. She recognizes the importance of promoting educational programs and nurturing the next generation of researchers.

In 2015, Dr. Yehudai-Reshef founded "Nevia Bio" (formerly Gina Life), a FemTech company dedicated to developing a platform for early diagnosis of various diseases in women. Currently, she serves as the Chief Scientist and a board member of the company.

Dr. Yehudai-Reshef's research approach is characterized by its multidisciplinary nature, drawing from her diverse expertise, skills, and knowledge. This combination contributes to her innovative and creative research endeavors, as she continues to make significant contributions in her field.