Rambam MedTech

Company: CAPS Medical

 

Non-thermal atmospheric (“cold”) plasma for minimally-invasive surgery and specific cell removal without collateral damage.Modalities can be developed for most minimally invasive procedures.

Company: H.V.T. Medical Technologies

 

A dedicated device for cusp splitting to prevent coronary obstruction post Trans-catheter Aortic Valve Implantation (TAVI). The risk of coronary obstruction is very high (~30%) in Valve-in–valve and TAVI-in-TAVI (~20%). Valve-in-valve: 5% with 50% risk to coronaries.

Company: Fluid Medical

 

Pancreatic cyst classification by analyzing the rheological behavior of pancreatic cyst fluid.

Company: Hanita lenses

 

A novel Intraocular lens (IOL) fixation device for a simple and safe surgical fixation technique following a cataract surgery. Intraocular lens subluxation or dislocation has been reported with increasing frequency, leading to concerns of a pending large increase in IOL dislocations needing surgical intervention.

A device for eye muscle surgery, consisting of a biodegradable clip and a cutting element. The device enables a quick, safe and accurate procedure.

Closed system Drug Transfer Device (CSTD) for oral dosage of cytotoxix drugs that combines the act of crushing, dissolving, and stirring in a liquid – all under aseptic, pressurized conditions for oral administration. Mechanically prohibits the transfer of environmental contaminants into the system and the escape of hazardous drugs or vapor of outside contaminants. Saves preparation time and decreases staff health risks.

A sticker surrounding any Catheter, electric wire, tubes, cables or any other instrument that penetrate the human body which includes a chamber of antibacterial liquid or antibacterial gel that is surrounding the penetration area and the penetrated instrument.
Status: Proof of concept

CAR-T cells with improved efficacy for the treatment of solid tumors

A peptide that inhibits the activity of Heparanase, thereby decreasing coagulation without increasing bleeding.

A device for controlled needle and thread passage through the sclera in eye surgery. In certain tissues, as in the eye, it is necessary to transfer a suture at a partial depth to prevent deep, uncontrolled penetration which can cause irreversible damage to the tissue and expose it to infections. Today the suturing is done manually and completely depends on human skills.

An orthopedic guide for performing guided phalange fracture reduction and fixation with k-wire, using an external guide device mounted on a fractured finger.

A “closed” and sterile system for preparation and injection of IV drugs at the patient's bedside (a “clean room” in a box).

A cassette, allowing the mixing of two solutions for the production of a chemically stable solution in general prior to use   that chemically eliminates the pain of injection.

A food supplement with the combined effects of L-arginine and sodium butyrate on GLP-1 and glucose levels in circulation; which reduces appetite in adults with obesity.

A new chemical composition for inhibition of Heparanase enzyme to treat pathogenesis of Acute Pancreatitis (AP).

Novel way to shorten the time it takes to place a Venous cannula while at the same time allowing the surgeon full control over the operation with no need of ultrasound.

A transcatheter myectomy device to fully eliminate ventricular septum without open surgery.
Myectomy in open heart surgery or alcohol septal ablation. Both methods have major problems (postoperative mortality and repeat procedures).

: Phills for Treating ovarian endometrial and renal cancer

Combination of quantitative image analysis tools (Radomics) with routine PSMA-PET output data increases prediction of metastatic disease in prostate adenocarcinoma patients. The technology is capable to predict the metastatic disease with high accuracy but with fair sensitivity and specificity.

An engineered protein – Sema 3C – for treating eye disorders and specifically age-related macular degeneration (AMD) and/or reducing abnormal angiogenesis and lymphangiogenesis in a patient’s eye.

An A-mode ultrasound-based apparatus, designed to ease the placement of epidural catheters in obese parturients

A new chemical molecule for treatment of chronic kidney disease targeting a specific cellular protein.

A peptide enhancing tissue factor activity for treatment in trauma and hemophilia bleeding. Long half-life and no thrombosis.

Raphael Pharmaceutical Inc. is a pioneering drug research and development company dedicated to discovering and advancing life-enhancing therapies based on cannabinoids. By collaborating with leading scientific experts and leveraging cutting-edge technologies, Raphael is committed to developing safe and effective cannabinoid-based treatments for a range of challenging medical conditions.
Raphael Pharmaceutical has established strategic partnerships with Rambam MedTech and The Shanti Medical Cannabis Research Center at Rambam Health Care Campus. These collaborations focus on investigating and deciphering the mechanisms which enable cannabinoids to be effective in the treatment of patients with various diseases, including:

• Rheumatoid arthritis (RA)
• COVID-19
• Lung inflammation
• Asthma
• Autoimmune diseases

Over the past five years, Raphael Pharmaceutical has invested approximately $3.5 million into these groundbreaking studies. This investment has resulted in signigicatn progress, including:

•  Authorization of a clinical trial for COVID-19 patients.
• A clinical proof-of-concept trial in the US evaluating Raphael's proprietary formula for RA patients, which recently concluded with highly encouraging results.
• Successful identification of a specific cannabis strain belonging to Raphael, which demonstrated the ability to attenuate chronic lung inflammation and asthma in both mouse models and human-derived immune cells.

Looking ahead, Raphael Pharmaceutical will continue these vital collaborations to explore cannabinoid-based formulas for diseases that currently lack effective solutions. By driving innovation and leveraging its partnerships, Raphael is committed to delivering transformative therapies to patients worldwide.