Dr. Shlomit Yehudai-Reshef - Details

Dr. Shlomit Yehudai-Reshef was born in Kibbutz Ma'ale Hachamisha. She completed her PhD in Biology in 2003 at the Technion – Israel Institute of Technology. Dr. Yehudai-Reshef pursued her postdoctoral research from 2003-2006 at Cornell University, New York, USA.

In 2008, she joined the Physics Department at the Technion, as a research-associate, where she conducted bio-physical research. This experience exposed Dr. Yehudai-Reshef to a new field in which she gained an expertise in live-cell imaging and image analysis.

In October 2012, she joined the Hematology Research Center at Rambam Health Care Campus and established the Leukemia research laboratory, located in the Clinical Research Institute at Rambam (CRIR), Haifa, Israel. She has been a member of the CRIR since 2016. In 2018 she was appointed CRIR-director. 

Dr. Yehudai-Reshef is an avid believer in the synergism of collaboration between physicians and scientists and she is passionate about translational research.  

Dr. Shlomit Yehudai-Reshef is currently leading the leukemia research laboratory together with Prof. Tsila Zuckerman. The laboratory focuses on acute myeloid leukemia (AML) and particularly on the regulation of the hematopoietic stem cell by its microenvironment, the bone marrow niche. Using a combination of genetics, imaging and functional assays, the laboratory has defined key components and abnormalities of the bone marrow niche and developed methods for altering niche interactions that have resulted in a pre-clinical experimental system using stem cells to model hematologic malignancies.

Dr. Yehudai-Reshefs' research is characterized by multidisciplinary approaches. Her broad set of expertise, skills and knowledge all contribute to an innovative and creative research. Her work has been published in leading journals and presented in many international meetings. Dr. Yehudai-Reshef is involved in many patented inventions.

Her academic and professional awards include: The Miriam and Aaron Gutwirth memorial fellowship for excellent Ph.D. students, The BARD Postdoctoral Fellowship, The Zeff fellowship trust, Postdoctoral Fellowship and the Lady Tata Memorial Trust: International Award for Innovative Research in Leukemia.

Dr. Yehudai-Reshef is married to Yoav and has three children.

Selected Publications

  1. Yehudai-Resheff S., Portnoy V., Yogev S., Adir N. and Schuster G. Domain Analysis of the Chloroplast Polynucleotide Phosphorylase Reveals Discrete Functions in RNA Degradation, Polyadenylation, and Sequence Homology with Exosome Proteins. Plant Cell 2003;15:2003-2019.

  2. Yehudai-Resheff S., Zimmer S.L., Komin Y. and Stern D.B. Integration of Chloroplast Nucleic Acid Metabolism into the Phosphate Deprivation Response in Chlamydomonas reinhardtii Plant Cell 2007;19:1023-1038.

  3. Portnoy V., Palnizky G., Yehudai-Resheff S., Glaser F. and Schuster G. Analysis of the human polynucleotide-phosphorylase (PNPase) reveals difference in RNA binding and response to phosphate compared to its bacterial and chloroplast counterparts. RNA 2007;14:297-309.

  4. Slomovic S., Portnoy V., Yehudai-Resheff S., Bronshtein E. and Schuster G. Polynucleotide phosphorylase and the archaeal exosome as poly(A)-polymerases. BBA - Gene Structure and Expression. 2008; 4:247-255.

  5. Irihimovitch V. and Yehudai-Resheff S. Phosphate and sulfur limitation responses in the chloroplast of Chlamydomonas reinhardtii. FEMS Microbiology Letters 2008;1:1.

  6. Marchive C., Yehudai-Resheff S., Germain A., Fei Z., Jiang X., Judkins J., Wu H., Fernie A.R., Fait A. and Stern D.B. Abnormal physiological and molecular mutant phenotypes link chloroplast polynucleotide phosphorylase to the phosphorus deprivation response in Arabidopsis. Plant Physiology 2009;15:905-924.

  7. Seroussi I., Veikherman D., Ofer N., Yehudai-Resheff S. and Keren K. Segmentation and tracking of live cells in phase-contrast images using directional gradient vector flow for snakes Journal of Microscopy 2012;247(2):137-146.

  8. Lieber A.D., Yehudai-Resheff S., Barnhart E.L., Theriot J.A. and Keren K. Membrane Tension in Rapidly Moving Cells Is Determined by Cytoskeletal Forces. Current Biology 2013;23(15):1409-1417.

  9. Shouval R, Shlush LI, Yehudai-Resheff S., Ali S, Pery N, Shapiro E, Tzukerman M, Rowe JM, Zuckerman T. Unraveling the heterogeneity of FLT3-ITD mutation in leukemia using single cell analysis. Exp. Hemato 2014;42(6):457–463.

  10. Raz-Ben Aroush D., Yehudai-Resheff S. and Keren K. Electrofusion of giant unilamellar vesicles to cells, Methods Cell Biol. 2015;125:409-22.

  11. Yehudai-Resheff S., Attias-Turgeman S., Sabbah R., Gabay T.,  Musallam R., Friedman-Dror A., Zuckerman T. Abnormal Morphological and Functional Nature of Bone Marrow Stromal Cells Provides Preferential Support for Survival of Acute Myeloid Leukemia Cells. Int J Cancer. 2019;144(9):2279-89.