The Khamaisi Lab

תמונה ראשית- Khamaisi Lab

The Khamaisi Lab

Addressing Diabetic Wound Healing

Principal Investigator: Prof. Mogher Khamaisi

Long-term diabetes is associated with a broad spectrum of vascular complications that constitute a major healthcare concern. Hyperglycemia-induced endothelial dysfunction results in serious complications, including diabetic foot ulcer. Research in our laboratory addresses diabetic wound healing in two major areas: stem cell utilization and enhancement of insulin activity.

Cell-based therapy using fibroblasts offer a promising approach to treat diabetic wound healing, due to the induced release of soluble growth factors and cytokines that stimulate new vessel formation and modulate inflammation. Stem cells could offer clinical benefits of revascularization and increased production of functional cells and tissues. At our laboratory, we aim to evaluate the function of induced pluripotent stem cells (iPSCs) originating from human fibroblasts to enhance diabetic wound healing. We also examine molecular modulation of insulin signaling in diabetic fibroblasts in order to overcome insulin resistance.

Autologous transplants emerge as a promising future modality in diabetes care. Our vision is providing an opportunity for in vitro sourcing of cells for regeneration and transplantation with the goal of revolutionizing diabetes care and vascular complications.

Meet the Khamaisi Lab Team>

The Khamaisi Lab

Prof. Mogher Khamaisi

Mogher Khamaisi, MD, PhD, is Director of the Department of Internal Medicine “D” at Rambam Health Care Campus. He is also an Associate Professor at the Rappaport Faculty of Medicine of the Technion-Israel Institute of Technology, where he conducts basic and clinical research.

Dr. Khamaisi completed B.S., M.Sc., and Ph.D. degrees in biology from Ben-Gurion University in Beer Sheva, all with honors. He graduated from Ben-Gurion University Medical School and completed his residency in the Department of Internal Medicine “B” at Hadassah Hospital Ein-Kerem in Jerusalem. He also completed a fellowship in Endocrinology, Diabetes, and Metabolism at Rambam. A board certified specialist in both Internal Medicine and Endocrinology, Dr. Khamaisi completed a post-doctoral research fellowship at the Joslin Diabetes Center at Harvard Medical School, working with the Director of Research, George L. King, and head of the Vascular Cell Biology unit, and holds two patents from his work at Harvard.

Prof. Mourir Khamaisi

As a member of the Clinical Research Institute of Rambam (CRIR), Dr. Khamaisi’s latest work in his lab continues to explore the molecular mechanisms involved in impaired wound healing in longstanding diabetes, particularly in chronic foot ulcer, a complication that leads to more than 2,000 amputations per year in Israel alone. He uses in vivo and in vitro studies, as well as human stem cells and other differentiated cells, to identify protective factors of diabetes-related vascular complications. His research currently utilizes inducible pluripotent stem cells (iPSCs) obtained from diabetics with longstanding disease, which differentiate into healthy endothelial cells and then are transplanted into a wound in an animal model.

Dr. Khamaisi has received numerous research grants and scientific awards, and has published over 75 scientific papers in prestigious international journals as well as book chapters and review articles.

Picture Gallery